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Goat Anti-FAPP2 / PLEKHA8 Antibody

Peptide-affinity purified goat antibody

  • IHC - Goat Anti-FAPP2 / PLEKHA8 Antibody AF1400a
    AF1400a (2.5 µg/ml) staining of paraffin embedded Human Placenta. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96JA3
Other Accession NP_116028, 84725
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 58261 Da
Additional Information
Gene ID 84725
Other Names Pleckstrin homology domain-containing family A member 8, PH domain-containing family A member 8, Phosphatidylinositol-four-phosphate adapter protein 2, FAPP-2, Phosphoinositol 4-phosphate adapter protein 2, hFAPP2, Serologically defined breast cancer antigen NY-BR-86, PLEKHA8, FAPP2
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-FAPP2 / PLEKHA8 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms FAPP2
Function Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans- Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation.
Cellular Location Cytoplasm. Golgi apparatus, trans-Golgi network membrane. Membrane; Peripheral membrane protein Note=Mainly localized to the trans-Golgi network (TGN) but also found at the rims of Golgi cisternae. Associates with ARF1 at Golgi apparatus membranes
Tissue Location Expressed in kidney cell lines.
Research Areas
Citations (0)

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FAPP2 gene downregulation increases tumor cell sensitivity to Fas-induced apoptosis. Tritz R, et al. Biochem Biophys Res Commun, 2009 May 29. PMID 19341712.
Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide. D'Angelo G, et al. Nature, 2007 Sep 6. PMID 17687330.
FAPP2 is involved in the transport of apical cargo in polarized MDCK cells. Vieira OV, et al. J Cell Biol, 2005 Aug 15. PMID 16103222.
FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P. Godi A, et al. Nat Cell Biol, 2004 May. PMID 15107860.
Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039.

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$ 325.00
Cat# AF1400a
(40 western blots)
Availability: 7-10 days
Bulk Size
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