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Goat Anti-FHL3 / SLIM2 Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q13643 |
| Other Accession | NP_004459, 2275, 56726 (mouse), 302363 (rat) |
| Reactivity | Human, Mouse, Rat |
| Predicted | Pig, Cow |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 100ug/200ul |
| Isotype | IgG |
| Calculated MW | 31192 Da |
| Gene ID | 2275 |
|---|---|
| Other Names | Four and a half LIM domains protein 3, FHL-3, Skeletal muscle LIM-protein 2, SLIM-2, FHL3, SLIM2 |
| Format | 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-FHL3 / SLIM2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FHL3 |
|---|---|
| Synonyms | SLIM2 |
| Function | Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1. |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q9R059}. Cytoplasm {ECO:0000250|UniProtKB:Q9R059} |
| Tissue Location | Expressed only in skeletal muscle. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
LIM proteins are defined by the possession of a highly conserved double zinc finger motif called the LIM domain.
References
Identification of the transactivation domain of the human FHL3. Huang X, et al. Mol Biol (Mosk), 2010 Mar-Apr. PMID 20586194.
Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-beta-like signaling pathway. Ding L, et al. J Clin Invest, 2009 Feb. PMID 19139564.
FHL3 binds MyoD and negatively regulates myotube formation. Cottle DL, et al. J Cell Sci, 2007 Apr 15. PMID 17389685.
Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514.
The SRF target gene Fhl2 antagonizes RhoA/MAL-dependent activation of SRF. Philippar U, et al. Mol Cell, 2004 Dec 22. PMID 15610731.
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