|Application ||WB, E|
|Other Accession||NP_004459, 2275, 56726 (mouse), 302363 (rat)|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||31192 Da|
|Other Names||Four and a half LIM domains protein 3, FHL-3, Skeletal muscle LIM-protein 2, SLIM-2, FHL3, SLIM2|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-FHL3 / SLIM2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Expressed only in skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
LIM proteins are defined by the possession of a highly conserved double zinc finger motif called the LIM domain.
Identification of the transactivation domain of the human FHL3. Huang X, et al. Mol Biol (Mosk), 2010 Mar-Apr. PMID 20586194.
Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-beta-like signaling pathway. Ding L, et al. J Clin Invest, 2009 Feb. PMID 19139564.
FHL3 binds MyoD and negatively regulates myotube formation. Cottle DL, et al. J Cell Sci, 2007 Apr 15. PMID 17389685.
Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514.
The SRF target gene Fhl2 antagonizes RhoA/MAL-dependent activation of SRF. Philippar U, et al. Mol Cell, 2004 Dec 22. PMID 15610731.
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