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Goat Anti-GAD1 (isoform GAD67) Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-GAD1 (isoform GAD67) Antibody AF1458a
    AF1458a (0.5 µg/ml) staining of Human Brain (Cerebral Cortex) lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q99259
Other Accession NP_000808, 2571, 14415 (mouse), 24379 (rat)
Reactivity Human
Predicted Mouse, Rat, Pig, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 66897 Da
Additional Information
Gene ID 2571
Other Names Glutamate decarboxylase 1,, 67 kDa glutamic acid decarboxylase, GAD-67, Glutamate decarboxylase 67 kDa isoform, GAD1, GAD, GAD67
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-GAD1 (isoform GAD67) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GAD1
Synonyms GAD, GAD67
Function Catalyzes the production of GABA.
Tissue Location Isoform 3 is expressed in pancreatic islets, testis, adrenal cortex, and perhaps other endocrine tissues, but not in brain.
Research Areas
Citations ( 0 )


This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.


Common variants conferring risk of schizophrenia: a pathway analysis of GWAS data. Jia P, et al. Schizophr Res, 2010 Sep. PMID 20659789.
Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891.
Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? Rua帽o G, et al. Pharmacogenomics, 2010 Jul. PMID 20602615.
Alcohol dependence and glutamate decarboxylase gene polymorphisms in an Italian male population. Terranova C, et al. Alcohol, 2010 Aug. PMID 20598486.
Genetic modulation of GABA levels in the anterior cingulate cortex by GAD1 and COMT. Marenco S, et al. Neuropsychopharmacology, 2010 Jul. PMID 20357758.

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$ 325.00
Cat# AF1458a
(40 western blots)
Availability: 7-10 days
Bulk Size
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