|Application ||WB, E|
|Other Accession||NP_002046, 2670, 14580 (mouse), 24387 (rat)|
|Calculated MW||49880 Da|
|Other Names||Glial fibrillary acidic protein, GFAP, GFAP|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-GFAP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||GFAP, a class-III intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.|
|Cellular Location||Cytoplasm. Note=Associated with intermediate filaments|
|Tissue Location||Expressed in cells lacking fibronectin.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia. Martins-de-Souza D, et al. J Psychiatr Res, 2010 May 14. PMID 20471030.
Withaferin A targets intermediate filaments glial fibrillary acidic protein and vimentin in a model of retinal gliosis. Bargagna-Mohan P, et al. J Biol Chem, 2010 Mar 5. PMID 20048155.
Specific human astrocyte subtype revealed by affinity purified GFAP antibody; unpurified serum cross-reacts with neurofilament-L in Alzheimer. Middeldorp J, et al. PLoS One, 2009 Nov 4. PMID 19888461.
Redox proteomic analysis of carbonylated brain proteins in mild cognitive impairment and early Alzheimer's disease. Sultana R, et al. Antioxid Redox Signal, 2010 Mar. PMID 19686046.
Glial fibrillary acidic protein in tumor types with cartilaginous differentiation. Santos GC, et al. Mod Pathol, 2009 Oct. PMID 19668151.
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