|Application ||WB, E|
|Other Accession||NP_974223, 10755, 67903 (mouse), 83823 (rat)|
|Predicted||Mouse, Rat, Cow|
|Calculated MW||36049 Da|
|Other Names||PDZ domain-containing protein GIPC1, GAIP C-terminus-interacting protein, RGS-GAIP-interacting protein, RGS19-interacting protein 1, Synectin, Tax interaction protein 2, TIP-2, GIPC1, C19orf3, GIPC, RGS19IP1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-GIPC1 / NIP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||C19orf3, GIPC, RGS19IP1|
|Function||May be involved in G protein-linked signaling.|
|Cellular Location||Cytoplasm. Membrane; Peripheral membrane protein|
|Tissue Location||Widely expressed.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
GIPC1 is a scaffolding protein that regulates cell surface receptor expression and trafficking (Lee et al., 2008 [PubMed 18775991]).
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Interaction of hepatitis B virus core protein with human GIPC1. Razanskas R, et al. Arch Virol, 2010 Feb. PMID 20091192.
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Talmud PJ, et al. Am J Hum Genet, 2009 Nov. PMID 19913121.
Overexpression of myosin VI in prostate cancer cells enhances PSA and VEGF secretion, but has no effect on endocytosis. Puri C, et al. Oncogene, 2010 Jan 14. PMID 19855435.
An essential role for the Glut1 PDZ-binding motif in growth factor regulation of Glut1 degradation and trafficking. Wieman HL, et al. Biochem J, 2009 Mar 1. PMID 19016655.
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