|Application ||WB, E|
|Other Accession||NP_848566, 139760|
|Calculated MW||36889 Da|
|Other Names||Glucose-dependent insulinotropic receptor, G-protein coupled receptor 119, GPR119|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-GPR119 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Predominantly expressed in the pancreas, especially in the islets.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the rhodopsin subfamily of G-protein-coupled receptors that is expressed in the pancreas and gastrointestinal tract. The encoded protein is activated by lipid amides including lysophosphatidylcholine and oleoylethanolamide and may be involved in glucose homeostasis. This protein is a potential drug target in the treatment of type 2 diabetes.
A conserved aromatic lock for the tryptophan rotameric switch in TM-VI of seven-transmembrane receptors. Holst B, et al. J Biol Chem, 2010 Feb 5. PMID 19920139.
N-oleoyldopamine enhances glucose homeostasis through the activation of GPR119. Chu ZL, et al. Mol Endocrinol, 2010 Jan. PMID 19901198.
Lipid receptors and islet function: therapeutic implications? Kebede MA, et al. Diabetes Obes Metab, 2009 Nov. PMID 19817784.
GPR119 agonists for the treatment of type 2 diabetes. Jones RM, et al. Expert Opin Ther Pat, 2009 Oct. PMID 19780700.
G-protein coupled receptors mediating long chain fatty acid signalling in the pancreatic beta-cell. Morgan NG, et al. Biochem Pharmacol, 2009 Dec 15. PMID 19660440.
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