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Goat Anti-GRB2 Antibody

Peptide-affinity purified goat antibody

  • IHC - Goat Anti-GRB2 Antibody AF1507a
    AF1507a (0.3 µg/ml) staining of paraffin embedded Human Tonsil. Microwaved antigen retrieval with citrate buffer pH6, HRP-staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P62993
Other Accession NP_987102, 2885, 14784 (mouse), 81504 (rat)
Reactivity Human, Mouse
Predicted Rat, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 25206 Da
Additional Information
Gene ID 2885
Other Names Growth factor receptor-bound protein 2, Adapter protein GRB2, Protein Ash, SH2/SH3 adapter GRB2, GRB2, ASH
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-GRB2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GRB2
Synonyms ASH
Function Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.
Cellular Location Nucleus. Cytoplasm. Endosome. Golgi apparatus
Research Areas
Citations (0)

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The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.


Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Association study of 182 candidate genes in anorexia nervosa. Pinheiro AP, et al. Am J Med Genet B Neuropsychiatr Genet, 2010 Jul. PMID 20468064.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
Preliminary crystallographic characterization of the Grb2 SH2 domain in complex with a FAK-derived phosphotyrosyl peptide. Chen HH, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 Feb 1. PMID 20124721.
Assembly of the Sos1-Grb2-Gab1 ternary signaling complex is under allosteric control. McDonald CB, et al. Arch Biochem Biophys, 2010 Feb 15. PMID 20005866.

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$ 325.00
Cat# AF1507a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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