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HADH / HADHSC AntibodyPeptide-affinity purified goat antibody
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AF1518a | 0.1mg 400 ul | 7-10 days | $ 325.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
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HADH / HADHSC Antibody - Product info | |
| Other Accession | NP_005318 |
| Reactivity | Human |
| Concentration | 100ug/200ul |
| Isotype | IgG |
HADH / HADHSC Antibody - Additional info | |
| Other Names HADH; HADHSC; hydroxyacyl-Coenzyme A dehydrogenase; HAD; HADH1; HHF4; M/SCHAD; MGC8392; SCHAD; L-3-hydroxyacyl-Coenzyme A dehydrogenase; L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain | |
| Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions HADH / HADHSC Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
HADH / HADHSC Antibody - Application data
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AF1518a (0.02 µg/ml) staining of Human Kidney lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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HEK293 overexpressing HADH (RC201752) with C-terminal tag (DYKDDDDK) and probed with anti-DYKDDDDK in the left panel. For full caption: see Application Notes.
HADH / HADHSC Antibody - Related products
AP10686c: HADH Antibody (Center)
AT2309a: HADHSC Antibody (monoclonal) (M01)
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BACKGROUND
This gene is a member of the 3-hydroxyacyl-CoA dehydrogenase gene family. The encoded protein functions in the mitochondrial matrix to catalyze the oxidation of straight-chain 3-hydroxyacyl-CoAs as part of the beta-oxidation pathway. Its enzymatic activity is highest with medium-chain-length fatty acids. Mutations in this gene cause one form of familial hyperinsulinemic hypoglycemia. The human genome contains a related pseudogene of this gene on chromosome 15.
REFERENCES
A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. Kalsi G, et al. Hum Mol Genet, 2010 Jun 15. PMID 20332099. Identification of a diffuse form of hyperinsulinemic hypoglycemia by 18-fluoro-L-3,4 dihydroxyphenylalanine positron emission tomography/CT in a patient carrying a novel mutation of the HADH gene. Di Candia S, et al. Eur J Endocrinol, 2009 Jun. PMID 19318379. The HADHSC gene encoding short-chain L-3-hydroxyacyl-CoA dehydrogenase (SCHAD) and type 2 diabetes susceptibility: the DAMAGE study. van Hove EC, et al. Diabetes, 2006 Nov. PMID 17065362. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560. 3-Hydroxyacyl-CoA dehydrogenase and short chain 3-hydroxyacyl-CoA dehydrogenase in human health and disease. Yang SY, et al. FEBS J, 2005 Oct. PMID 16176262.
