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Goat Anti-IRF6 Antibody

Peptide-affinity purified goat antibody

  • IHC - Goat Anti-IRF6 Antibody AF1572a
    AF1572a (2.5 µg/ml) staining of paraffin embedded Human Kidney. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
  • WB - Goat Anti-IRF6 Antibody AF1572a
    AF1572a staining (0.2 µg/ml) of Human Ovary lysate (RIPA buffer, 35 µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
  • WB - Goat Anti-IRF6 Antibody AF1572a
    HEK293 overexpressing IRF6 (RC201579) and probed with AF1572a (mock transfection in first lane), tested by Origene.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O14896
Other Accession NP_006138, 3664, 54139 (mouse)
Reactivity Human
Predicted Mouse
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 53130 Da
Additional Information
Gene ID 3664
Other Names Interferon regulatory factor 6, IRF-6, IRF6
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-IRF6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IRF6
Function Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development (By similarity). Plays a role in regulating mammary epithelial cell proliferation (By similarity). May regulate WDR65 transcription (By similarity).
Cellular Location Nucleus. Cytoplasm Note=Translocates to nucleus in response to an activating signal
Tissue Location Expressed in normal mammary epithelial cells. Expression is reduced or absent in breast carcinomas
Research Areas
Citations (0)

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This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. This protein is involved in palate formation.


IRF6 polymorphisms are associated with nonsyndromic orofacial clefts in a Chinese Han population. Pan Y, et al. Am J Med Genet A, 2010 Aug 26. PMID 20799332.
Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate. Nikopensius T, et al. Birth Defects Res A Clin Mol Teratol, 2010 Jul 29. PMID 20672350.
Evidence of gene-environment interaction for the IRF6 gene and maternal multivitamin supplementation in controlling the risk of cleft lip with/without cleft palate. Wu T, et al. Hum Genet, 2010 Oct. PMID 20652317.
Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891.
MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate. Jagom脌gi T, et al. Eur J Oral Sci, 2010 Jun. PMID 20572854.

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$ 325.00
Cat# AF1572a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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