|Application ||WB, E|
|Other Accession||NP_861463, 3784, 16535 (mouse), 84020 (rat)|
|Predicted||Mouse, Rat, Dog, Cow|
|Calculated MW||74699 Da|
|Other Names||Potassium voltage-gated channel subfamily KQT member 1, IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1, KQT-like 1, Voltage-gated potassium channel subunit Kv7.1, KCNQ1, KCNA8, KCNA9, KVLQT1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-KCNQ1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KCNA8, KCNA9, KVLQT1|
|Function||Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea.|
|Cellular Location||Cell membrane; Multi-pass membrane protein Cytoplasmic vesicle membrane; Multi- pass membrane protein|
|Tissue Location||Abundantly expressed in heart, pancreas, prostate, kidney, small intestine and peripheral blood leukocytes Less abundant in placenta, lung, spleen, colon, thymus, testis and ovaries|
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This gene encodes a protein for a voltage-gated potassium channel required for the repolarization phase of the cardiac action potential. The gene product can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome, Romano-Ward syndrome, Jervell and Lange-Nielsen syndrome and familial atrial fibrillation. The gene is located in a region of chromosome 11 that contains a large number of contiguous genes that are abnormally imprinted in cancer and the Beckwith-Wiedemann syndrome. Two alternative transcripts encoding distinct isoforms have been described.
Obesity and diabetes genetic variants associated with gestational weight gain. Stuebe AM, et al. Am J Obstet Gynecol, 2010 Sep. PMID 20816152.
Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion. Heni M, et al. Diabetes, 2010 Aug 29. PMID 20802253.
KCNQ1 gene polymorphisms are associated with lipid parameters in a Chinese Han population. Chen Z, et al. Cardiovasc Diabetol, 2010 Aug 11. PMID 20701788.
COMMON VARIANTS IN 40 GENES ASSESSED FOR DIABETES INCIDENCE AND RESPONSE TO METFORMIN AND LIFESTYLE INTERVENTIONS IN THE DIABETES PREVENTION PROGRAM. Jablonski KA, et al. Diabetes, 2010 Aug 3. PMID 20682687.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
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