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Goat Anti-KLF15 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-KLF15 Antibody AF1593a
    AF1593a (0.5 µg/ml) staining of Human Kidney lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UIH9
Other Accession NP_054798.1, 28999, 66277 (mouse), 85497 (rat)
Reactivity Human
Predicted Mouse, Rat, Pig
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 43992 Da
Additional Information
Gene ID 28999
Other Names Krueppel-like factor 15, Kidney-enriched krueppel-like factor, KLF15, KKLF
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-KLF15 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KLF15
Synonyms KKLF
Function Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CTGF expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation.
Cellular Location Nucleus
Tissue Location Highly expressed in liver, skeletal muscle, and kidney. Expressed in cardiomyocytes. Expression is highly reduced in cardiac tissue of patients with non-ischemic cardiomyopathy and aortic aneurysm, and in glomerular disease. Not expressed in bone marrow or lymphoid tissues
Research Areas
Citations (0)

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Sp1 and KLF15 regulate basal transcription of the human LRP5 gene. Li J, et al. BMC Genet, 2010 Feb 8. PMID 20141633.
KLF15 Is a transcriptional regulator of the human 17beta-hydroxysteroid dehydrogenase type 5 gene. A potential link between regulation of testosterone production and fat stores in women. Du X, et al. J Clin Endocrinol Metab, 2009 Jul. PMID 19366843.
The Kruppel-like factor KLF15 inhibits connective tissue growth factor (CTGF) expression in cardiac fibroblasts. Wang B, et al. J Mol Cell Cardiol, 2008 Aug. PMID 18586263.
Analysis of KLF transcription factor family gene variants in type 2 diabetes. Guti茅rrez-Aguilar R, et al. BMC Med Genet, 2007 Aug 9. PMID 17688680.
Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy. Fisch S, et al. Proc Natl Acad Sci U S A, 2007 Apr 24. PMID 17438289.

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$ 325.00
Cat# AF1593a
(40 western blots)
Availability: 7-10 days
Bulk Size
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