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Goat Anti-KLF8 / BKLF3 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-KLF8 / BKLF3 Antibody AF1597a
    AF1597a staining (2 µg/ml) of Human Kidney lysate (RIPA buffer, 30 µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O95600
Other Accession NP_001152768, 11279
Reactivity Human
Predicted Pig
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 39314 Da
Additional Information
Gene ID 11279
Other Names Krueppel-like factor 8, Basic krueppel-like factor 3, Zinc finger protein 741, KLF8, BKLF3, ZNF741
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-KLF8 / BKLF3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KLF8
Synonyms BKLF3, ZNF741
Function Transcriptional repressor and activator. Binds to CACCC- boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK).
Cellular Location Nucleus.
Tissue Location Ubiquitous..
Research Areas
Citations (0)

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This gene encodes a protein which is a member of the Sp/KLF family of transcription factors. Members of this family contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers. The encoded protein is thought to play an important role in the regulation of epithelial to mesenchymal transition, a process which occurs normally during development but also during metastasis. A pseudogene has been identified on chromosome 16. Alternative splicing results in multiple transcript variants.


Small interference RNA targeting Kr脤ppel-like factor 8 inhibits the renal carcinoma 786-0 cells growth in vitro and in vivo. Fu WJ, et al. J Cancer Res Clin Oncol, 2010 Aug. PMID 20182889.
Activation of KLF8 transcription by focal adhesion kinase in human ovarian epithelial and cancer cells. Wang X, et al. J Biol Chem, 2008 May 16. PMID 18353772.
Kr脤ppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion. Wang X, et al. Cancer Res, 2007 Aug 1. PMID 17671186.
Systematic RNAi studies on the role of Sp/KLF factors in globin gene expression and erythroid differentiation. Hu JH, et al. J Mol Biol, 2007 Mar 2. PMID 17224162.
KLF8 transcription factor participates in oncogenic transformation. Wang X, et al. Oncogene, 2007 Jan 18. PMID 16832343.

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$ 325.00
Cat# AF1597a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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