|Application ||WB, E|
|Other Accession||NP_001152768, 11279|
|Calculated MW||39314 Da|
|Other Names||Krueppel-like factor 8, Basic krueppel-like factor 3, Zinc finger protein 741, KLF8, BKLF3, ZNF741|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-KLF8 / BKLF3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional repressor and activator. Binds to CACCC- boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein which is a member of the Sp/KLF family of transcription factors. Members of this family contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers. The encoded protein is thought to play an important role in the regulation of epithelial to mesenchymal transition, a process which occurs normally during development but also during metastasis. A pseudogene has been identified on chromosome 16. Alternative splicing results in multiple transcript variants.
Small interference RNA targeting Kr脤ppel-like factor 8 inhibits the renal carcinoma 786-0 cells growth in vitro and in vivo. Fu WJ, et al. J Cancer Res Clin Oncol, 2010 Aug. PMID 20182889.
Activation of KLF8 transcription by focal adhesion kinase in human ovarian epithelial and cancer cells. Wang X, et al. J Biol Chem, 2008 May 16. PMID 18353772.
Kr脤ppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion. Wang X, et al. Cancer Res, 2007 Aug 1. PMID 17671186.
Systematic RNAi studies on the role of Sp/KLF factors in globin gene expression and erythroid differentiation. Hu JH, et al. J Mol Biol, 2007 Mar 2. PMID 17224162.
KLF8 transcription factor participates in oncogenic transformation. Wang X, et al. Oncogene, 2007 Jan 18. PMID 16832343.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.