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Goat Anti-LIG1 / DNA ligase I Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-LIG1 / DNA ligase I Antibody AF1623a
    AF1623a (0.1 µg/ml) staining of HeLa nuclear lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P18858
Other Accession NP_000225, 3978, 81513 (rat)
Reactivity Human
Predicted Rat
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 101736 Da
Additional Information
Gene ID 3978
Other Names DNA ligase 1,, DNA ligase I, Polydeoxyribonucleotide synthase [ATP] 1, LIG1
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-LIG1 / DNA ligase I Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LIG1
Function DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
Cellular Location Nucleus.
Research Areas
Citations (0)

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LIG1 encodes DNA ligase I, with functions in DNA replication and the base excision repair process. Mutations in LIG1 that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents.


Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
XPC genetic polymorphisms correlate with the response to imatinib treatment in patients with chronic phase chronic myeloid leukemia. Guillem VM, et al. Am J Hematol, 2010 Jul. PMID 20575039.
Polymorphisms in the base excision repair pathway and graft-versus-host disease. Arora M, et al. Leukemia, 2010 Aug. PMID 20574454.
Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk. Monsees GM, et al. Breast Cancer Res Treat, 2010 May 23. PMID 20496165.
A Large-scale genetic association study of esophageal adenocarcinoma risk. Liu CY, et al. Carcinogenesis, 2010 Jul. PMID 20453000.

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$ 325.00
Cat# AF1623a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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