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Goat Anti-LXR alpha / LXR beta Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-LXR alpha / LXR beta Antibody AF1638a
    AF1638a (1 µg/ml) staining of human spleen lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P55055
Other Accession NP_009052, 10062, 7376
Reactivity Human, Mouse, Rat
Predicted Cow, Dog
Host Goat
Clonality Polyclonal
Concentration 0.5mg/ml
Isotype IgG
Calculated MW 50974 Da
Additional Information
Gene ID 7376
Other Names Oxysterols receptor LXR-beta, Liver X receptor beta, Nuclear receptor NER, Nuclear receptor subfamily 1 group H member 2, Ubiquitously-expressed nuclear receptor, NR1H2, LXRB, NER, UNR
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-LXR alpha / LXR beta Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NR1H2
Synonyms LXRB, NER, UNR
Function Nuclear receptor. Binds preferentially to double- stranded oligonucleotide direct repeats having the consensus half- site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}
Tissue Location Ubiquitous.
Research Areas
Citations ( 0 )


The liver X receptors, LXRA and LXRB (NR1H2; MIM 600380), form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).


Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086. Activation of liver X receptor sensitizes human dendritic cells to inflammatory stimuli. T枚r枚csik D, et al. J Immunol, 2010 May 15. PMID 20410489. LXR activation inhibits chemokine-induced CD4-positive lymphocyte migration. Walcher D, et al. Basic Res Cardiol, 2010 Jul. PMID 20364260. New genetic associations detected in a host response study to hepatitis B vaccine. Davila S, et al. Genes Immun, 2010 Apr. PMID 20237496. Liver X Receptor activation downregulates AKT survival signaling in lipid rafts and induces apoptosis of prostate cancer cells. Pommier AJ, et al. Oncogene, 2010 May 6. PMID 20190811.

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$ 325.00
Cat# AF1638a
(40 western blots)
Availability: 7-10 days
Bulk Size
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