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Goat Anti-MC2R / ACTHR Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-MC2R / ACTHR Antibody AF1658a
    AF1658a (1 µg/ml) staining of Human Skin lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q01718
Other Accession NP_000520, 4158
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 33927 Da
Additional Information
Gene ID 4158
Other Names Adrenocorticotropic hormone receptor, ACTH receptor, ACTH-R, Adrenocorticotropin receptor, Melanocortin receptor 2, MC2-R, MC2R, ACTHR
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-MC2R / ACTHR Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MC2R
Synonyms ACTHR
Function Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP).
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Melanocytes and corticoadrenal tissue.
Research Areas
Citations (0)

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MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency.


Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium. Canzian F, et al. Hum Mol Genet, 2010 Oct 1. PMID 20634197.
Genetic variation in neuroendocrine genes associates with somatic symptoms in the general population: results from the EPIFUND study. Holliday KL, et al. J Psychosom Res, 2010 May. PMID 20403506.
ACTH receptor (MC2R) promoter variants associated with infantile spasms modulate MC2R expression and responsiveness to ACTH. Ding YX, et al. Pharmacogenet Genomics, 2010 Feb. PMID 20042918.
Role of asparagine-linked glycosylation in cell surface expression and function of the human adrenocorticotropin receptor (melanocortin 2 receptor) in 293/FRT cells. Roy S, et al. Endocrinology, 2010 Feb. PMID 20022931.
Isolated Addison's disease is unlikely to be caused by mutations in MC2R, MRAP or STAR, three genes responsible for familial glucocorticoid deficiency. Dias RP, et al. Eur J Endocrinol, 2010 Feb. PMID 19903795.

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$ 325.00
Cat# AF1658a
(40 western blots)
Availability: 7-10 days
Bulk Size
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