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Goat Anti-Monoglyceride Lipase Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-Monoglyceride Lipase Antibody AF1678a
    AF1678a (0.5 µg/ml) staining of Human Adipose lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • WB - Goat Anti-Monoglyceride Lipase Antibody AF1678a
    HEK293 overexpressing MGLL (RC218358) and probed with AF1678a (mock transfection in first lane), tested by Origene.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q99685
Other Accession NP_001003794, 11343, 23945 (mouse), 29254 (rat)
Reactivity Human
Predicted Mouse, Rat, Pig, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 33261 Da
Additional Information
Gene ID 11343
Other Names Monoglyceride lipase, MGL,, HU-K5, Lysophospholipase homolog, Lysophospholipase-like, Monoacylglycerol lipase, MAGL, MGLL
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-Monoglyceride Lipase Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MGLL (HGNC:17038)
Function Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (PubMed:20079333).
Cellular Location Cytoplasm, cytosol {ECO:0000250|UniProtKB:O35678}. Membrane {ECO:0000250|UniProtKB:O35678}; Peripheral membrane protein {ECO:0000250|UniProtKB:O35678}
Tissue Location Detected in adipose tissue, lung, liver, kidney, brain and heart.
Research Areas
Citations (0)

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Monoglyceride lipase (MGLL; EC functions together with hormone-sensitive lipase (LIPE; MIM 151750) to hydrolyze intracellular triglyceride stores in adipocytes and other cells to fatty acids and glycerol. MGLL may also complement lipoprotein lipase (LPL; MIM 238600) in completing hydrolysis of monoglycerides resulting from degradation of lipoprotein triglycerides (Karlsson et al., 2001 [PubMed 11470505]).


Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis. Nomura DK, et al. Cell, 2010 Jan 8. PMID 20079333.
Structural basis for human monoglyceride lipase inhibition. Bertrand T, et al. J Mol Biol, 2010 Feb 26. PMID 19962385.
Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signaling. Labar G, et al. Chembiochem, 2010 Jan 25. PMID 19957260.
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Talmud PJ, et al. Am J Hum Genet, 2009 Nov. PMID 19913121.

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$ 325.00
Cat# AF1678a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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