|Application ||WB, E|
|Other Accession||NP_001157962, 101, 11501 (mouse)|
|Calculated MW||88771 Da|
|Other Names||Disintegrin and metalloproteinase domain-containing protein 8, ADAM 8, 3.4.24.-, Cell surface antigen MS2, CD156a, ADAM8, MS2|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-MS2 / ADAM8 / CD156 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Possible involvement in extravasation of leukocytes.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed on neutrophils and monocytes.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants.
Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility hot-spot. Johnatty SE, et al. PLoS Genet, 2010 Jul 8. PMID 20628624.
Novel alternatively spliced ADAM8 isoforms contribute to the aggressive bone metastatic phenotype of lung cancer. Hern谩ndez I, et al. Oncogene, 2010 Jul 1. PMID 20453887.
ADAM8 substrate specificity: influence of pH on pre-processing and proteoglycan degradation. Hall T, et al. Arch Biochem Biophys, 2009 Nov. PMID 19766586.
ADAM-8 isolated from human osteoarthritic chondrocytes cleaves fibronectin at Ala(271). Zack MD, et al. Arthritis Rheum, 2009 Sep. PMID 19714641.
ADAM8/MS2/CD156, an emerging drug target in the treatment of inflammatory and invasive pathologies. Koller G, et al. Curr Pharm Des, 2009. PMID 19601829.
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