|Application ||WB, IHC, E|
|Other Accession||NP_002439, 4487, 17701 (mouse)|
|Predicted||Mouse, Rat, Pig, Cow|
|Calculated MW||31496 Da|
|Other Names||Homeobox protein MSX-1, Homeobox protein Hox-7, Msh homeobox 1-like protein, MSX1, HOX7|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-MSX1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity.|
|Tissue Location||Expressed in the developing nail bed mesenchyme.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the muscle segment homeobox gene family. The encoded protein functions as a transcriptional repressor during embryogenesis through interactions with components of the core transcription complex and other homeoproteins. It may also have roles in limb-pattern formation, craniofacial development, particularly odontogenesis, and tumor growth inhibition. Mutations in this gene, which was once known as homeobox 7, have been associated with nonsyndromic cleft lip with or without cleft palate 5, Witkop syndrome, Wolf-Hirschom syndrome, and autosomoal dominant hypodontia.
Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate. Nikopensius T, et al. Birth Defects Res A Clin Mol Teratol, 2010 Jul 29. PMID 20672350.
The c.469+46_56del mutation in the homeobox MSX1 gene-A novel risk factor in breast cancer? Sliwinski T, et al. Cancer Epidemiol, 2010 Jul 16. PMID 20638926.
Parent-of-origin effects for MSX1 in a Chilean population with nonsyndromic cleft lip/palate. Suazo J, et al. Am J Med Genet A, 2010 Aug. PMID 20635363.
Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891.
MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate. Jagom脌gi T, et al. Eur J Oral Sci, 2010 Jun. PMID 20572854.
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