|Application ||WB, E|
|Other Accession||NP_001121897, 4595|
|Calculated MW||60069 Da|
|Other Names||A/G-specific adenine DNA glycosylase, 3.2.2.-, MutY homolog, hMYH, MUTYH, MYH|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-MUTYH Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2- OH-A DNA glycosylase activities.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
Simplifying the detection of MUTYH mutations by high resolution melting analysis. L贸pez-Villar I, et al. BMC Cancer, 2010 Aug 5. PMID 20687945.
An in-frame exon-skipping MUTYH mutation is associated with early-onset colorectal cancer. Fostira F, et al. Dis Colon Rectum, 2010 Aug. PMID 20628285.
MUTYH-associated polyposis - variability of the clinical phenotype in patients with biallelic and monoallelic MUTYH mutations and report on novel mutations. Morak M, et al. Clin Genet, 2010 Jun 10. PMID 20618354.
Polymorphisms in the base excision repair pathway and graft-versus-host disease. Arora M, et al. Leukemia, 2010 Aug. PMID 20574454.
MUTYH Tyr165Cys, OGG1 Ser326Cys and XPD Lys751Gln polymorphisms and head neck cancer susceptibility: a case control study. Sliwinski T, et al. Mol Biol Rep, 2010 Jun 23. PMID 20571908.
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