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Goat Anti-MYD88 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-MYD88 Antibody AF1701a
    AF1701a staining (0.03 µg/ml) of human thymus lysate (RIPA buffer, 35 µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
  • IHC - Goat Anti-MYD88 Antibody AF1701a
    AF1701a (4 µg/ml) staining of paraffin embedded Human Tonsil. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining. These results could not been obtained after antigen retireval at pH6 with this batch of antibody.
  • EIA - Goat Anti-MYD88 Antibody AF1701a
    AF1701a (5ug/ml) as the reporter with EB002006 as the capture rabbit antibody (5ug/ml).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q99836
Other Accession NP_002459, 4615, 17874 (mouse), 301059 (rat)
Reactivity Human
Predicted Mouse, Rat, Dog
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 33233 Da
Additional Information
Gene ID 4615
Other Names Myeloid differentiation primary response protein MyD88, MYD88
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-MYD88 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MYD88
Function Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine.
Cellular Location Cytoplasm
Tissue Location Ubiquitous..
Research Areas
Citations ( 0 )


This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants.


The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88. He B, et al. Nat Immunol, 2010 Sep. PMID 20676093.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Dengue hemorrhagic fever is associated with polymorphisms in JAK1. Silva LK, et al. Eur J Hum Genet, 2010 Jun 30. PMID 20588308.
Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling. Lin SC, et al. Nature, 2010 Jun 17. PMID 20485341.
Role of polymorphic variants as genetic modulators of infection in neonatal sepsis. Abu-Maziad A, et al. Pediatr Res, 2010 Oct. PMID 20463618.

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$ 325.00
Cat# AF1701a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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