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Goat Anti-NET1 / ARHGEF8 (C Terminus) Antibody

Peptide-affinity purified goat antibody

  • IHC - Goat Anti-NET1 / ARHGEF8 (C Terminus) Antibody AF1717a
    AF1717a (2.5 µg/ml) staining of paraffin embedded Human Tonsil. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q7Z628
Other Accession NP_005854, 10276
Reactivity Human
Predicted Mouse
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 67740 Da
Additional Information
Gene ID 10276
Other Names Neuroepithelial cell-transforming gene 1 protein, Proto-oncogene p65 Net1, Rho guanine nucleotide exchange factor 8, NET1, ARHGEF8
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-NET1 / ARHGEF8 (C Terminus) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NET1
Synonyms ARHGEF8
Function Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.
Cellular Location Cytoplasm. Nucleus
Tissue Location Widely expressed.
Research Areas
Citations (0)

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Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.
Interaction of the RhoA exchange factor Net1 with discs large homolog 1 protects it from proteasome-mediated degradation and potentiates Net1 activity. Carr HS, et al. J Biol Chem, 2009 Sep 4. PMID 19586902.
Coexpression of alpha6beta4 integrin and guanine nucleotide exchange factor Net1 identifies node-positive breast cancer patients at high risk for distant metastasis. Gilcrease MZ, et al. Cancer Epidemiol Biomarkers Prev, 2009 Jan. PMID 19124484.
NET1-mediated RhoA activation facilitates lysophosphatidic acid-induced cell migration and invasion in gastric cancer. Murray D, et al. Br J Cancer, 2008 Oct 21. PMID 18827818.
A bacterial cytotoxin identifies the RhoA exchange factor Net1 as a key effector in the response to DNA damage. Guerra L, et al. PLoS One, 2008 May 28. PMID 18509476.

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$ 325.00
Cat# AF1717a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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