|Application ||WB, E|
|Other Accession||NP_004549, 4902|
|Calculated MW||22405 Da|
|Other Names||Neurturin, NRTN|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-Neurturin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells.|
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Provided below are standard protocols that you may find useful for product applications.
Neurturin is a member of the TGF-beta subfamily, TRN. This gene signals through RET and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease.
Polymorphisms in the genes encoding the 4 RET ligands, GDNF, NTN, ARTN, PSPN, and susceptibility to Hirschsprung disease. Fernandez RM, et al. J Pediatr Surg, 2008 Nov. PMID 18970938.
Expression patterns of the glial cell line-derived neurotrophic factor, neurturin, their cognate receptors GFRalpha-1, GFRalpha-2, and a common signal transduction element c-Ret in the human skin hair follicles. Adly MA, et al. J Am Acad Dermatol, 2008 Feb. PMID 18222320.
Glial cell line-derived neurotrophic factor and neurturin inhibit neurite outgrowth and activate RhoA through GFR alpha 2b, an alternatively spliced isoform of GFR alpha 2. Yoong LF, et al. J Neurosci, 2007 May 23. PMID 17522305.
Glial cell-line derived neurotrophic factor and neurturin regulate the expressions of distinct miRNA precursors through the activation of GFRalpha2. Yoong LF, et al. J Neurochem, 2006 Aug. PMID 16895582.
Expression and function of glial cell line-derived neurotrophic factor family ligands and their receptors on human immune cells. Vargas-Leal V, et al. J Immunol, 2005 Aug 15. PMID 16081799.
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