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Goat Anti-PAI1 / SERPINE1 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-PAI1 / SERPINE1 Antibody AF1777a
    AF1777a (0.3 µg/ml) staining of Human Liver lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • WB - Goat Anti-PAI1 / SERPINE1 Antibody AF1777a
    AF1777a (0.1 µg/ml) staining of A549 (A), HepG2 (B) and HeLa (C) lysates (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • IHC - Goat Anti-PAI1 / SERPINE1 Antibody AF1777a
    AF1777a (4 µg/ml) staining of paraffin embedded Human Placenta. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining.
  • EIA - Goat Anti-PAI1 / SERPINE1 Antibody AF1777a
    AF1777a (1.5ug/ml) as the reporter with EB002011 as the capture rabbit antibody (2.5ug/ml).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P05121
Other Accession NP_001158885, 5054
Reactivity Human
Predicted Dog
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 45060 Da
Additional Information
Gene ID 5054
Other Names Plasminogen activator inhibitor 1, PAI, PAI-1, Endothelial plasminogen activator inhibitor, Serpin E1, SERPINE1, PAI1, PLANH1
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-PAI1 / SERPINE1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms PAI1, PLANH1
Function Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.
Cellular Location Secreted.
Tissue Location Found in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells
Research Areas
Citations (0)

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This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.


The Role of Plasminogen Activator Inhibitor-1 and Angiotensin-Converting Enzyme Gene Polymorphisms in Bronchopulmonary Dysplasia. Ince DA, et al. Genet Test Mol Biomarkers, 2010 Sep 6. PMID 20818980. Tumour budding, uPA and PAI-1 are associated with aggressive behaviour in colon cancer. M脌rkl B, et al. J Surg Oncol, 2010 Sep 1. PMID 20740581. Association of PAI-1 gene polymorphism with survival and chemotherapy-related vascular toxicity in testicular cancer. de Haas EC, et al. Cancer, 2010 Aug 24. PMID 20737565. Failure to lyse venous thrombi because of elevated plasminogen activator Inhibitor 1 (PAI-1) and 4G polymorphism of its promotor genome (The PAI-1/4G Syndrome). Bern MM, et al. Clin Appl Thromb Hemost, 2010 Oct. PMID 20724304. Evaluation of the Association of Urokinase Plasminogen Activator System Gene Polymorphisms with Susceptibility and Pathological Development of Hepatocellular Carcinoma. Weng CJ, et al. Ann Surg Oncol, 2010 Aug 13. PMID 20706793.

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$ 325.00
Cat# AF1777a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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