|Application ||WB, E|
|Other Accession||NP_002845, 5816|
|Calculated MW||12059 Da|
|Other Names||Parvalbumin alpha, PVALB|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-Parvalbumin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a high affinity calcium ion-binding protein that is structurally and functionally similar to calmodulin and troponin C. The encoded protein is thought to be involved in muscle relaxation.
Parvalbumin: Targeting calcium handling in cardiac diastolic dysfunction. Wang W, et al. Gen Physiol Biophys, 2009. PMID 20093724.
Evaluating PVALB as a candidate gene for SLC12A3-negative cases of Gitelman's syndrome. Riveira-Munoz E, et al. Nephrol Dial Transplant, 2008 Oct. PMID 18469313.
Distribution of parvalbumin and calretinin immunoreactive interneurons in motor cortex from multiple sclerosis post-mortem tissue. Clements RJ, et al. Exp Brain Res, 2008 May. PMID 18297277.
Quantitative analysis of parvalbumin-immunoreactive cells in the human epileptic hippocampus. Andrioli A, et al. Neuroscience, 2007 Oct 12. PMID 17850980.
Strongly reduced number of parvalbumin-immunoreactive projection neurons in the mammillary bodies in schizophrenia: further evidence for limbic neuropathology. Bernstein HG, et al. Ann N Y Acad Sci, 2007 Jan. PMID 17405923.
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