|Application ||WB, E|
|Other Accession||NP_005009, 5133|
|Predicted||Mouse, Rat, Dog, Cow|
|Calculated MW||31647 Da|
|Other Names||Programmed cell death protein 1, Protein PD-1, hPD-1, CD279, PDCD1, PD1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-PDCD1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen- specific manner. Possible cell death inducer, in association with other factors.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.
Association Between Hepatitis B Viral Burden in Chronic Infection and a Functional Single Nucleotide Polymorphism of the PDCD1 Gene. Zheng L, et al. J Clin Immunol, 2010 Aug 11. PMID 20700634.
[Study on the relationship of the haplotypes of programmed cell death 1 gene and ultraviolet history with systemic lupus erythematosus.] Peng C, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2010 Aug. PMID 20677149.
[Programmed cell death 1 (PDCD1) gene polymorphisms and type 1 diabetes in Chilean children] Flores S, et al. Rev Med Chil, 2010 May. PMID 20668808.
Role played by the programmed death-1-programmed death ligand pathway during innate immunity against Mycobacterium tuberculosis. Alvarez IB, et al. J Infect Dis, 2010 Aug 15. PMID 20617899.
PTPN22, PDCD1 and CYP27B1 polymorphisms and susceptibility to type 1 diabetes in Polish patients. Fichna M, et al. Int J Immunogenet, 2010 Jun 1. PMID 20518841.
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