|Application ||WB, E|
|Other Accession||NP_071404, 64065, 64058 (mouse), 292949 (rat)|
|Predicted||Mouse, Rat, Dog|
|Calculated MW||21386 Da|
|Other Names||p53 apoptosis effector related to PMP-22, Keratinocyte-associated protein 1, KCP-1, P53-induced protein PIGPC1, Transmembrane protein THW, PERP, KCP1, KRTCAP1, PIGPC1, THW|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-PERP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KCP1, KRTCAP1, PIGPC1, THW|
|Function||Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway (By similarity).|
|Cellular Location||Cell junction, desmosome. Cell membrane; Multi-pass membrane protein Note=Associated with desmosomes.|
|Tissue Location||Expressed in skin, heart, placental, liver, pancreas, keratinocytes and dermal fibroblasts|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
A Large-scale genetic association study of esophageal adenocarcinoma risk. Liu CY, et al. Carcinogenesis, 2010 Jul. PMID 20453000.
Single-nucleotide polymorphisms in the p53 pathway genes modify cancer risk in BRCA1 and BRCA2 carriers of Jewish-Ashkenazi descent. Yarden RI, et al. Mol Carcinog, 2010 Jun. PMID 20306497.
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Talmud PJ, et al. Am J Hum Genet, 2009 Nov. PMID 19913121.
Differential PERP regulation by TP63 mutants provides insight into AEC pathogenesis. Beaudry VG, et al. Am J Med Genet A, 2009 Sep. PMID 19353588.
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