|Application ||WB, IHC, E|
|Other Accession||NP_006234, 5525|
|Predicted||Rat, Pig, Dog, Cow|
|Calculated MW||56194 Da|
|Other Names||Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform, PP2A B subunit isoform B'-alpha, PP2A B subunit isoform B56-alpha, PP2A B subunit isoform PR61-alpha, PR61alpha, PP2A B subunit isoform R5-alpha, PPP2R5A|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-PPP2R5A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.|
|Cellular Location||Cytoplasm. Nucleus. Chromosome, centromere. Note=From mitotic prophase to metaphase, localizes at the inner centromere between a pair of sister kinetochores. Decreased expression at the onset of anaphase.|
|Tissue Location||Widely expressed with the highest expression in heart and skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B56 subfamily.
Nuclear export and centrosome targeting of the protein phosphatase 2A subunit B56alpha: role of B56alpha in nuclear export of the catalytic subunit. Flegg CP, et al. J Biol Chem, 2010 Jun 11. PMID 20378546.
Negative regulation of CHK2 activity by protein phosphatase 2A is modulated by DNA damage. Freeman AK, et al. Cell Cycle, 2010 Feb 15. PMID 20160490.
The Balpha and Bdelta regulatory subunits of PP2A are necessary for assembly of the CaMKIV.PP2A signaling complex. Reece KM, et al. Biochem Biophys Res Commun, 2009 Sep 4. PMID 19538941.
Lysine-independent turnover of cyclin G1 can be stabilized by B'alpha subunits of protein phosphatase 2A. Li H, et al. Mol Cell Biol, 2009 Feb. PMID 18981217.
PKR regulates B56(alpha)-mediated BCL2 phosphatase activity in acute lymphoblastic leukemia-derived REH cells. Ruvolo VR, et al. J Biol Chem, 2008 Dec 19. PMID 18957415.
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