|Application ||WB, E|
|Other Accession||NP_851308, 5528|
|Predicted||Mouse, Rat, Pig, Dog, Cow|
|Calculated MW||69992 Da|
|Other Names||Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform, PP2A B subunit isoform B'-delta, PP2A B subunit isoform B56-delta, PP2A B subunit isoform PR61-delta, PP2A B subunit isoform R5-delta, PPP2R5D|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-PPP2R5D Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.|
|Cellular Location||Cytoplasm. Nucleus. Note=Nuclear in interphase, nuclear during mitosis|
|Tissue Location||Isoform Delta-2 is widely expressed. Isoform Delta-1 is highly expressed in brain|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a delta isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.
Phosphorylation on the PPP2R5D B regulatory subunit modulates the biochemical properties of protein phosphatase 2A. Yu UY, et al. BMB Rep, 2010 Apr. PMID 20423611.
The Balpha and Bdelta regulatory subunits of PP2A are necessary for assembly of the CaMKIV.PP2A signaling complex. Reece KM, et al. Biochem Biophys Res Commun, 2009 Sep 4. PMID 19538941.
A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. Goudreault M, et al. Mol Cell Proteomics, 2009 Jan. PMID 18782753.
PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4. Chen GI, et al. J Biol Chem, 2008 Oct 24. PMID 18715871.
Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1. Forester CM, et al. Proc Natl Acad Sci U S A, 2007 Dec 11. PMID 18056802.
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