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Peptide-affinity purified goat antibody
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Application 
| WB, E |
|---|---|
| Primary Accession | Q9Y4L5 |
| Other Accession | NP_055270, 27246, 67845 (mouse), 362002 (rat) |
| Reactivity | Human |
| Predicted | Mouse, Rat, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5mg/ml |
| Isotype | IgG |
| Calculated MW | 33703 Da |
| Gene ID | 27246 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase RNF115, 6.3.2.-, RING finger protein 115 {ECO:0000312|HGNC:HGNC:18154}, Rabring 7, RNF115 (HGNC:18154) |
| Format | 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-Rabring 7 / BCA2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RNF115 (HGNC:18154) |
|---|---|
| Function | E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates and may play a role in diverse biological processes. Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4. |
| Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9D0C1}. Note=The GTP-bound form of RAB7A recruits RNF115 from the cytosol onto late endosomes/lysosomes {ECO:0000250|UniProtKB:Q9D0C1} |
| Tissue Location | Expressed at extremely low levels in normal breast, prostate, lung, colon. Higher levels of expression are detected in heart, skeletal muscle, testis as well as in breast and prostate cancer cells. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614. New genetic associations detected in a host response study to hepatitis B vaccine. Davila S, et al. Genes Immun, 2010 Apr. PMID 20237496. BCA2/Rabring7 promotes tetherin-dependent HIV-1 restriction. Miyakawa K, et al. PLoS Pathog, 2009 Dec. PMID 20019814. Autoubiquitination of BCA2 RING E3 ligase regulates its own stability and affects cell migration. Amemiya Y, et al. Mol Cancer Res, 2008 Sep. PMID 18819927. Involvement of Rabring7 in EGF receptor degradation as an E3 ligase. Sakane A, et al. Biochem Biophys Res Commun, 2007 Jun 15. PMID 17462600.
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