|Application ||WB, E|
|Other Accession||NP_004649, 8437|
|Calculated MW||90016 Da|
|Other Names||RasGAP-activating-like protein 1, RASAL1, RASAL|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-RASAL Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probable inhibitory regulator of the Ras-cyclic AMP pathway.|
|Tissue Location||Highly expressed in thyroid and adrenal medulla, lower expression in brain, spinal cord and trachea|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described
Decreased expression of the RAS-GTPase activating protein RASAL1 is associated with colorectal tumor progression. Ohta M, et al. Gastroenterology, 2009 Jan. PMID 18992247.
Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers. Jin H, et al. Proc Natl Acad Sci U S A, 2007 Jul 24. PMID 17640920.
CAPRI and RASAL impose different modes of information processing on Ras due to contrasting temporal filtering of Ca2+. Liu Q, et al. J Cell Biol, 2005 Jul 18. PMID 16009725.
A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity. Kolfschoten IG, et al. Cell, 2005 Jun 17. PMID 15960973.
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
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