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Goat Anti-RASAL Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-RASAL Antibody AF1914a
    AF1914a (0.3 µg/ml) staining of Human Thyroid lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O95294
Other Accession NP_004649, 8437
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 90016 Da
Additional Information
Gene ID 8437
Other Names RasGAP-activating-like protein 1, RASAL1, RASAL
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-RASAL Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms RASAL
Function Probable inhibitory regulator of the Ras-cyclic AMP pathway.
Tissue Location Highly expressed in thyroid and adrenal medulla, lower expression in brain, spinal cord and trachea
Research Areas
Citations (0)

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The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described


Decreased expression of the RAS-GTPase activating protein RASAL1 is associated with colorectal tumor progression. Ohta M, et al. Gastroenterology, 2009 Jan. PMID 18992247.
Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers. Jin H, et al. Proc Natl Acad Sci U S A, 2007 Jul 24. PMID 17640920.
CAPRI and RASAL impose different modes of information processing on Ras due to contrasting temporal filtering of Ca2+. Liu Q, et al. J Cell Biol, 2005 Jul 18. PMID 16009725.
A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity. Kolfschoten IG, et al. Cell, 2005 Jun 17. PMID 15960973.
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.

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$ 325.00
Cat# AF1914a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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