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Goat Anti-SBP2 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-SBP2 Antibody AF1961a
    AF1961a staining of HFF cell lysate with B) 100nM siRNA or A) control siRNA. Detected by chemiluminescence. Data kindly provided by Laura Papp and Kum Kum Khanna, Brisbane, Australia.
  • IHC - Goat Anti-SBP2 Antibody AF1961a
    AF1961a (3 µg/ml) staining of paraffin embedded Human Testis. Microwaved antigen retrieval with Tris/EDTA buffer pH9, HRP-staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96T21
Other Accession NP_076982, 79048
Reactivity Human, Mouse
Predicted Pig, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 95462 Da
Additional Information
Gene ID 79048
Other Names Selenocysteine insertion sequence-binding protein 2, SECIS-binding protein 2, SECISBP2, SBP2
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-SBP2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms SBP2
Function Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB.
Cellular Location Isoform 1: Nucleus.
Tissue Location Expressed at high levels in testis.
Research Areas
Citations (0)

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The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. The gene described in this record encodes a nuclear protein that functions as a SECIS binding protein. Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism.


Genetic variants in selenoprotein genes increase risk of colorectal cancer. M茅plan C, et al. Carcinogenesis, 2010 Jun. PMID 20378690.
SECIS-binding protein 2 promotes cell survival by protecting against oxidative stress. Papp LV, et al. Antioxid Redox Signal, 2010 Apr 1. PMID 19803747.
Clinical and molecular characterization of a novel selenocysteine insertion sequence-binding protein 2 (SBP2) gene mutation (R128X). Di Cosmo C, et al. J Clin Endocrinol Metab, 2009 Oct. PMID 19602558.
SECIS-binding protein 2, a key player in selenoprotein synthesis, is an intrinsically disordered protein. Oli茅ric V, et al. Biochimie, 2009 Aug. PMID 19467292.
Selenium supplementation fails to correct the selenoprotein synthesis defect in subjects with SBP2 gene mutations. Schomburg L, et al. Thyroid, 2009 Mar. PMID 19265499.

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$ 325.00
Cat# AF1961a
(40 western blots)
Availability: 7-10 days
Bulk Size
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