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Goat Anti-SEPT6 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-SEPT6 Antibody AF1970a
    AF1970a (1 µg/ml) staining of Human Testis lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • IHC - Goat Anti-SEPT6 Antibody AF1970a
    AF1970a (3.8 µg/ml) staining of paraffin embedded Human Tonsil. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q14141
Other Accession NP_665801, 23157
Reactivity Human
Predicted Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 49717 Da
Additional Information
Gene ID 23157
Other Names Septin-6, SEPT6, KIAA0128, SEP2
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-SEPT6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SEPT6
Synonyms KIAA0128, SEP2
Function Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication.
Cellular Location Cytoplasm. Cytoplasm, cytoskeleton, spindle Chromosome, centromere, kinetochore Cleavage furrow. Midbody. Note=In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle
Tissue Location Widely expressed.
Research Areas
Citations (0)

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This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined.


SEPT12 interacts with SEPT6 and this interaction alters the filament structure of SEPT6 in Hela cells. Ding X, et al. J Biochem Mol Biol, 2007 Nov 30. PMID 18047794.
Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.
Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7. Kremer BE, et al. Cell, 2007 Sep 7. PMID 17803907.
Structural insight into filament formation by mammalian septins. Sirajuddin M, et al. Nature, 2007 Sep 20. PMID 17637674.
An RNA-binding protein, hnRNP A1, and a scaffold protein, septin 6, facilitate hepatitis C virus replication. Kim CS, et al. J Virol, 2007 Apr. PMID 17229681.

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$ 325.00
Cat# AF1970a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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