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Goat Anti-SHP2 / PTPN11 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-SHP2 / PTPN11 Antibody AF1988a
    AF1988a staining (2 µg/ml) of human muscle lysate (RIPA buffer, 35 µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
  • WB - Goat Anti-SHP2 / PTPN11 Antibody AF1988a
    HEK293 overexpressing PTPN11 (RC220029) and probed with AF1988a (mock transfection in first lane), tested by Origene.
  • IHC - Goat Anti-SHP2 / PTPN11 Antibody AF1988a
    AF1988a (3.8 µg/ml) staining of paraffin embedded Human Cerebellum Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q06124
Other Accession NP_002825, 5781, 19247 (mouse), 25622 (rat)
Reactivity Human, Mouse
Predicted Rat, Pig, Cow
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 68436 Da
Additional Information
Gene ID 5781
Other Names Tyrosine-protein phosphatase non-receptor type 11,, Protein-tyrosine phosphatase 1D, PTP-1D, Protein-tyrosine phosphatase 2C, PTP-2C, SH-PTP2, SHP-2, Shp2, SH-PTP3, PTPN11, PTP2C, SHPTP2
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-SHP2 / PTPN11 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PTPN11
Synonyms PTP2C, SHPTP2
Function Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.
Cellular Location Cytoplasm.
Tissue Location Widely expressed, with highest levels in heart, brain, and skeletal muscle.
Research Areas
Citations (0)

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The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.


[Expression and its clinical significance of SHP2 in non-small cell lung cancer] Tang C, et al. Zhongguo Fei Ai Za Zhi, 2010 Feb. PMID 20673499.
Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891.
The language phenotype of children and adolescents with Noonan syndrome. Pierpont EI, et al. J Speech Lang Hear Res, 2010 Aug. PMID 20543023.
Integrin beta4 attenuates SHP-2 and MAPK signaling and reduces human lung endothelial inflammatory responses. Chen W, et al. J Cell Biochem, 2010 Jun 1. PMID 20512931.
Importance of protein-tyrosine phosphatase-alpha catalytic domains for interactions with SHP-2 and interleukin-1-induced matrix metalloproteinase-3 expression. Wang Q, et al. J Biol Chem, 2010 Jul 16. PMID 20472558.

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$ 325.00
Cat# AF1988a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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