|Application ||WB, E|
|Other Accession||NP_004722, 9194|
|Calculated MW||52200 Da|
|Other Names||Monocarboxylate transporter 2, MCT 2, Solute carrier family 16 member 7, SLC16A7, MCT2|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-SLC16A7 / MCT2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Functions as high-affinity pyruvate transporter.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Detected in heart and in blood lymphocytes and monocytes (at protein level). High expression in testis, moderate to low in spleen, heart, kidney, pancreas, skeletal muscle, brain and Leukocyte. Restricted expression in normal tissues, but widely expressed in cancer cells.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Expression of monocarboxylate transporters 1, 2, and 4 in human tumours and their association with CD147 and CD44. Pinheiro C, et al. J Biomed Biotechnol, 2010. PMID 20454640.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
Monocarboxylate transport in human corneal epithelium and cell lines. Vellonen KS, et al. Eur J Pharm Sci, 2010 Feb 19. PMID 20035863.
Hypoxia stimulates lactate release and modulates monocarboxylate transporter (MCT1, MCT2, and MCT4) expression in human adipocytes. P茅rez de Heredia F, et al. Pflugers Arch, 2010 Feb. PMID 19876643.
Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. Wheeler HE, et al. PLoS Genet, 2009 Oct. PMID 19834535.
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