|Application ||WB, E|
|Other Accession||NP_003100, 6667|
|Predicted||Rat, Pig, Dog, Cow|
|Calculated MW||80693 Da|
|Other Names||Transcription factor Sp1, SP1, TSFP1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-SP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component ARNTL/BMAL1.|
|Cellular Location||Nucleus. Cytoplasm. Note=Nuclear location is governed by glycosylated/phosphorylated states. Insulin promotes nuclear location, while glucagon favors cytoplasmic location|
|Tissue Location||Up-regulated in adenocarcinomas of the stomach (at protein level). Isoform 3 is ubiquitously expressed at low levels.|
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Provided below are standard protocols that you may find useful for product applications.
Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation. Jutooru I, et al. J Biol Chem, 2010 Aug 13. PMID 20538607.
Sp1 binds to the external promoter of the p73 gene and induces the expression of TAp73gamma in lung cancer. Logotheti S, et al. FEBS J, 2010 Jul. PMID 20528922.
Regulation of plasma-membrane-associated sialidase NEU3 gene by Sp1/Sp3 transcription factors. Yamaguchi K, et al. Biochem J, 2010 Aug 15. PMID 20518744.
Transcription factor Sp1 regulates expression of cancer-associated molecule CD147 in human lung cancer. Kong LM, et al. Cancer Sci, 2010 Jun. PMID 20384626.
HDAC4 inhibits the transcriptional activation of mda-7/IL-24 induced by Sp1. Pan L, et al. Cell Mol Immunol, 2010 May. PMID 20383178.
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