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Goat Anti-SSP29 / ANP32B Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | Q92688 |
| Other Accession | NP_006392, 10541, 67628 (mouse), 170724 (rat) |
| Reactivity | Human |
| Predicted | Mouse, Rat, Pig, Dog, Cow |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 100ug/200ul |
| Isotype | IgG |
| Calculated MW | 28788 Da |
| Gene ID | 10541 |
|---|---|
| Other Names | Acidic leucine-rich nuclear phosphoprotein 32 family member B, Acidic protein rich in leucines, Putative HLA-DR-associated protein I-2, PHAPI2, Silver-stainable protein SSP29, ANP32B, APRIL, PHAPI2 |
| Format | 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-SSP29 / ANP32B Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ANP32B |
|---|---|
| Synonyms | APRIL, PHAPI2 |
| Function | Multifunctional protein that is involved in the regulation of many processes including cell proliferation, apoptosis, cell cycle progression or transcription (PubMed:20015864, PubMed:18039846). Regulates the proliferation of neuronal stem cells, differentiation of leukemic cells and progression from G1 to S phase of the cell cycle. As negative regulator of caspase-3-dependent apoptosis, may act as an antagonist of ANP32A in regulating tissue homeostasis (PubMed:20015864). Exhibits histone chaperone properties, able to recruit histones to certain promoters, thus regulating the transcription of specific genes (PubMed:20538007, PubMed:18039846). Also plays an essential role in the nucleocytoplasmic transport of specific mRNAs via the uncommon nuclear mRNA export receptor XPO1/CRM1 (PubMed:17178712). Participates in the regulation of adequate adaptive immune responses by acting on mRNA expression and cell proliferation (By similarity). |
| Cellular Location | [Isoform 1]: Nucleus. Cytoplasm Note=Accumulates in the nuclei at the S phase. |
| Tissue Location | Expressed in heart, lung, pancreas, prostate and in spleen, thymus and placenta. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Solution structure of histone chaperone ANP32B: interaction with core histones H3-H4 through its acidic concave domain. Tochio N, et al. J Mol Biol, 2010 Aug 6. PMID 20538007.
Downregulation of ANP32B, a novel substrate of caspase-3, enhances caspase-3 activation and apoptosis induction in myeloid leukemic cells. Shen SM, et al. Carcinogenesis, 2010 Mar. PMID 20015864.
Phosphorylation of the HuR ligand APRIL by casein kinase 2 regulates CD83 expression. Chemnitz J, et al. Eur J Immunol, 2009 Jan. PMID 19130553.
Promoter region-specific histone incorporation by the novel histone chaperone ANP32B and DNA-binding factor KLF5. Munemasa Y, et al. Mol Cell Biol, 2008 Feb. PMID 18039846.
Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Jeronimo C, et al. Mol Cell, 2007 Jul 20. PMID 17643375.
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