|Application ||WB, IHC, E|
|Other Accession||NP_001013863, 55620|
|Calculated MW||44894 Da|
|Other Names||Signal-transducing adaptor protein 2, STAP-2, Breast tumor kinase substrate, BRK substrate, STAP2, BKS|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-STAP2 / BKS Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Substrate of protein kinase PTK6. May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity.|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes the substrate of breast tumor kinase, an Src-type non-receptor tyrosine kinase. The encoded protein possesses domains and several tyrosine phosphorylation sites characteristic of adaptor proteins that mediate the interactions linking proteins involved in signal transduction pathways. Alternative splicing results in multiple transcript variants.
An approach based on a genome-wide association study reveals candidate loci for narcolepsy. Shimada M, et al. Hum Genet, 2010 Oct. PMID 20677014.
Signal-transducing adaptor protein-2 regulates stromal cell-derived factor-1 alpha-induced chemotaxis in T cells. Sekine Y, et al. J Immunol, 2009 Dec 15. PMID 19933863.
The protein content of an adaptor protein, STAP-2 is controlled by E3 ubiquitin ligase Cbl. Sekine Y, et al. Biochem Biophys Res Commun, 2009 Jun 26. PMID 19401194.
STAP-2 is phosphorylated at tyrosine-250 by Brk and modulates Brk-mediated STAT3 activation. Ikeda O, et al. Biochem Biophys Res Commun, 2009 Jun 19. PMID 19393627.
STAP-2 negatively regulates both canonical and noncanonical NF-kappaB activation induced by Epstein-Barr virus-derived latent membrane protein 1. Ikeda O, et al. Mol Cell Biol, 2008 Aug. PMID 18573890.
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