|Application ||WB, IHC, E|
|Other Accession||NP_077305, 79180, 27984 (mouse)|
|Predicted||Rat, Dog, Cow|
|Calculated MW||26697 Da|
|Other Names||EF-hand domain-containing protein D2, Swiprosin-1, EFHD2, SWS1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-Swiprosin 1 / EFHD2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance.|
|Cellular Location||Membrane raft. Note=In a mouse immature B-cell line WEHI-231.|
|Tissue Location||Found in lymphocytes; preferentially expressed in CD8+ cells.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia. Martins-de-Souza D, et al. J Psychiatr Res, 2010 May 14. PMID 20471030.
Swiprosin-1 is expressed in mast cells and up-regulated through the protein kinase C beta I/eta pathway. Thylur RP, et al. J Cell Biochem, 2009 Oct 15. PMID 19693767.
Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia. Martins-de-Souza D, et al. Eur Arch Psychiatry Clin Neurosci, 2009 Apr. PMID 19165527.
The novel adaptor protein Swiprosin-1 enhances BCR signals and contributes to BCR-induced apoptosis. Avramidou A, et al. Cell Death Differ, 2007 Nov. PMID 17673920.
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Olsen JV, et al. Cell, 2006 Nov 3. PMID 17081983.
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