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Goat Anti-TDP-43 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-TDP-43 Antibody AF2067a
    AF2067a (0.3 µg/ml) staining of Jurkat lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • WB - Goat Anti-TDP-43 Antibody AF2067a
    AF2067a (1 µg/ml) staining of Human Cerebellum (A), Frontal Cotex (B) and Hippocampus (C) lysates (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13148
Other Accession NP_031401, 23435, 230908 (mouse)
Reactivity Human, Mouse
Predicted Rat, Pig, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 44740 Da
Additional Information
Gene ID 23435
Other Names TAR DNA-binding protein 43, TDP-43, TARDBP, TDP43
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-TDP-43 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms TDP43
Function DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.
Cellular Location Nucleus. Note=In patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis, it is absent from the nucleus of affected neurons but it is the primary component of cytoplasmic ubiquitin-positive inclusion bodies
Tissue Location Ubiquitously expressed. In particular, expression is high in pancreas, placenta, lung, genital tract and spleen
Research Areas
Citations (0)

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HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.


TARDBP gene mutations among Chinese patients with sporadic amyotrophic lateral sclerosis. Huang R, et al. Neurobiol Aging, 2010 Aug 12. PMID 20708823.
Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice. Xu YF, et al. J Neurosci, 2010 Aug 11. PMID 20702714.
Amyotrophic lateral sclerosis-frontotemporal lobar dementia in 3 families with p.Ala382Thr TARDBP mutations. Chi貌 A, et al. Arch Neurol, 2010 Aug. PMID 20697052.
Large-scale screening of TARDBP mutation in amyotrophic lateral sclerosis in Japanese. Iida A, et al. Neurobiol Aging, 2010 Jul 30. PMID 20675015.
TARDBP Mutations in Frontotemporal Lobar Degeneration: Frequency, Clinical Features, and Disease Course. Borroni B, et al. Rejuvenation Res, 2010 Jul 20. PMID 20645878.

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$ 325.00
Cat# AF2067a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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