|Application ||WB, IHC, E|
|Other Accession||NP_003362, 7410, 22325 (mouse)|
|Predicted||Mouse, Rat, Pig, Dog|
|Calculated MW||101289 Da|
|Other Names||Guanine nucleotide exchange factor VAV2, VAV-2, VAV2|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-VAV2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity).|
|Tissue Location||Widely expressed.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis. Nischwitz S, et al. J Neuroimmunol, 2010 Oct 8. PMID 20598377.
Variations in NTF4, VAV2 and VAV3 Genes Are Not Involved With Primary Open Angle and Primary Angle Closure Glaucomas in an Indian Population. Rao KN, et al. Invest Ophthalmol Vis Sci, 2010 May 12. PMID 20463313.
Balanced Vav2 GEF activity regulates neurite outgrowth and branching in vitro and in vivo. Moon MS, et al. Mol Cell Neurosci, 2010 Jun. PMID 20298788.
VAV2 regulates epidermal growth factor receptor endocytosis and degradation. Thalappilly S, et al. Oncogene, 2010 Apr 29. PMID 20140013.
Mutation of ARHGAP9 in patients with coronary spastic angina. Takefuji M, et al. J Hum Genet, 2010 Jan. PMID 19911011.
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