|Application ||WB, E|
|Other Accession||NP_803490, 4232, 17294 (mouse), 58827 (rat)|
|Predicted||Human, Dog, Cow|
|Calculated MW||38830 Da|
|Other Names||Mesoderm-specific transcript homolog protein, 3.-.-.-, Paternally-expressed gene 1 protein, MEST, PEG1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-MEST Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Highly expressed in hydatidiform moles, but barely expressed in dermoid cysts. Biallelic expression is detected in blood lymphocytes. Seems to imprinted in an isoform- specific manner rather than in a tissue-specific manner in lymphocytes. Isoform 1 is expressed only from the paternal allele Isoform 2 is expressed from both the paternal allele and the maternal allele.|
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This gene encodes a member of the [alpha]/[beta] hydrolase fold family and has isoform specific imprinting. The loss of imprinting of this gene has been linked to certain types of cancer and may be due to promotor switching. The encoded protein may play a role in development. Three transcript variants encoding two distinct isoforms have been identified for this gene. A pseudogene for this locus is located on chromosome 6.
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