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Goat Anti-INDOL1 Antibody

Peptide-affinity purified goat antibody

     
  • WB - Goat Anti-INDOL1 Antibody AF2190a
    AF2190a (0.5 µg/ml) staining of Human Kidney lysate (35 µg protein in RIPA buffer) with (B) and without (A) blocking with the immunising peptide. Primary incubation was 1 hour. Detected by chemiluminescence.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q6ZQW0
Other Accession NP_919270, 169355
Reactivity Human
Predicted Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Calculated MW 47075 Da
Additional Information
Gene ID 169355
Other Names Indoleamine 2, 3-dioxygenase 2, IDO-2, 1.13.11.-, Indoleamine 2, 3-dioxygenase-like protein 1, Indoleamine-pyrrole 2, 3-dioxygenase-like protein 1, IDO2, INDOL1
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-INDOL1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IDO2
Synonyms INDOL1
Function Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in immune regulation. May not play a significant role in tryptophan-related tumoral resistance (PubMed:25691885).
Tissue Location Detected in liver, small intestine, spleen, placenta, thymus, lung, brain, kidney, and colon (PubMed:17671174). Also expressed at low level in testis and thyroid. Not expressed in the majority of human tumor samples (>99%) (PubMed:25691885).
Research Areas
Citations (0)

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Background

Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]).

References

Induction of indoleamine 2, 3-dioxygenase by death receptor activation contributes to apoptosis of melanoma cells via mitochondrial damage-dependent ROS accumulation. Cetindere T, et al. Cell Signal, 2010 Feb. PMID 19799997.
High activity of indoleamine 2,3 dioxygenase enzyme predicts disease severity and case fatality in bacteremic patients. Huttunen R, et al. Shock, 2010 Feb. PMID 19487973.
Genotyping and expression analysis of IDO2 in human pancreatic cancer: a novel, active target. Witkiewicz AK, et al. J Am Coll Surg, 2009 May. PMID 19476837.
Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan. Metz R, et al. Cancer Res, 2007 Aug 1. PMID 17671174.
Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice. Ball HJ, et al. Gene, 2007 Jul 1. PMID 17499941.

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$ 335.00
Cat# AF2190a
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