|Application ||WB, E|
|Other Accession||NP_919270, 169355|
|Calculated MW||47075 Da|
|Other Names||Indoleamine 2, 3-dioxygenase 2, IDO-2, 1.13.11.-, Indoleamine 2, 3-dioxygenase-like protein 1, Indoleamine-pyrrole 2, 3-dioxygenase-like protein 1, IDO2, INDOL1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-INDOL1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in immune regulation. May not play a significant role in tryptophan-related tumoral resistance (PubMed:25691885).|
|Tissue Location||Detected in liver, small intestine, spleen, placenta, thymus, lung, brain, kidney, and colon (PubMed:17671174). Also expressed at low level in testis and thyroid. Not expressed in the majority of human tumor samples (>99%) (PubMed:25691885).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]).
Induction of indoleamine 2, 3-dioxygenase by death receptor activation contributes to apoptosis of melanoma cells via mitochondrial damage-dependent ROS accumulation. Cetindere T, et al. Cell Signal, 2010 Feb. PMID 19799997.
High activity of indoleamine 2,3 dioxygenase enzyme predicts disease severity and case fatality in bacteremic patients. Huttunen R, et al. Shock, 2010 Feb. PMID 19487973.
Genotyping and expression analysis of IDO2 in human pancreatic cancer: a novel, active target. Witkiewicz AK, et al. J Am Coll Surg, 2009 May. PMID 19476837.
Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan. Metz R, et al. Cancer Res, 2007 Aug 1. PMID 17671174.
Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice. Ball HJ, et al. Gene, 2007 Jul 1. PMID 17499941.
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