|Application ||WB, E|
|Other Accession||NP_004663, 9064, 313022 (mouse), 53608 (rat)|
|Predicted||Human, Mouse, Dog, Cow|
|Calculated MW||142596 Da|
|Other Names||Mitogen-activated protein kinase kinase kinase 6, 126.96.36.199, Apoptosis signal-regulating kinase 2, MAP3K6, ASK2, MAPKKK6, MEKK6|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-MAP3K6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ASK2, MAPKKK6, MEKK6|
|Function||Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the serine/threonine protein kinase family. The encoded kinase was identified by its interaction with MAP3K5/ASK, a protein kinase and an activator of c-Jun kinase (MAPK7/JNK) and MAPK14/p38 kinase. This kinase was found to weakly activate MAPK7, but not MAPK1/ERK or MAPK14. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Talmud PJ, et al. Am J Hum Genet, 2009 Nov. PMID 19913121.
Mitogen-activated protein 3 kinase 6 mediates angiogenic and tumorigenic effects via vascular endothelial growth factor expression. Eto N, et al. Am J Pathol, 2009 Apr. PMID 19246638.
ASK1 and MAP2K6 as modifiers of age at onset in Huntington's disease. Arning L, et al. J Mol Med, 2008 Apr. PMID 18327563.
Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1. Takeda K, et al. J Biol Chem, 2007 Mar 9. PMID 17210579.
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