|Application ||WB, IHC, E|
|Other Accession||NP_659399, 157310|
|Calculated MW||25733 Da|
|Other Names||Phosphatidylethanolamine-binding protein 4, PEBP-4, hPEBP4, Protein cousin-of-RKIP 1, PEBP4, CORK1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-PEBP4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Seems to promote cellular resistance to TNF-induced apoptosis by inhibiting activation of the Raf-1/MEK/ERK pathway, JNK and phosphatidylethanolamine externalization.|
|Tissue Location||Ubiquitously expressed. Highly expressed in tumor cells.|
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Provided below are standard protocols that you may find useful for product applications.
The phosphatidylethanolamine (PE)-binding proteins, including PEBP4, are an evolutionarily conserved family of proteins with pivotal biologic functions, such as lipid binding and inhibition of serine proteases (Wang et al., 2004 [PubMed 15302887]).
Human phosphatidylethanolamine-binding protein 4 promotes transactivation of estrogen receptor alpha (ERalpha) in human cancer cells by inhibiting proteasome-dependent ERalpha degradation via association with Src. Liu H, et al. J Biol Chem, 2010 Jul 16. PMID 20460377.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. Trynka G, et al. Gut, 2009 Aug. PMID 19240061.
Regulation of human myoblast differentiation by PEBP4. Garcia R, et al. EMBO Rep, 2009 Mar. PMID 19197339.
Molecular genetics of successful smoking cessation: convergent genome-wide association study results. Uhl GR, et al. Arch Gen Psychiatry, 2008 Jun. PMID 18519826.
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