Goat Anti-INCA / CARD17 Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q5XLA6 |
Other Accession | NP_001007233, 440068 |
Reactivity | Human |
Host | Goat |
Clonality | Polyclonal |
Concentration | 100ug/200ul |
Isotype | IgG |
Calculated MW | 11868 Da |
Other Names | Caspase recruitment domain-containing protein 17, Caspase-1 inhibitor INCA, Inhibitory caspase recruitment domain protein, CARD17, INCA |
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Format | 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Goat Anti-INCA / CARD17 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CARD17P |
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Synonyms | CARD17, INCA |
Function | Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation. |
Cellular Location | Cytoplasm. |
Tissue Location | Ubiquitous.. |
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Provided below are standard protocols that you may find useful for product applications.
References
INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation. Lamkanfi M, et al. J Biol Chem, 2004 Dec 10. PMID 15383541.
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