|Application ||IHC, E|
|Other Accession||NP_001035025.1, NP_004058.1, 1124|
|Predicted||Mouse, Dog, Cow|
|Calculated MW||53924 Da|
|Other Names||Beta-chimaerin, Beta-chimerin, Rho GTPase-activating protein 3, CHN2, ARHGAP3, BCH|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CHN2 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors.|
|Cellular Location||Membrane; Peripheral membrane protein|
|Tissue Location||Highest levels in the brain and pancreas. Also expressed in the heart, placenta, and weakly in the kidney and liver. Expression is much reduced in the malignant gliomas, compared to normal brain or low-grade astrocytomas|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both reported isoforms (NP_004058.1; NP_001035025.1).
T cell receptor-dependent tyrosine phosphorylation of beta2-chimaerin modulates its Rac-GAP function in T cells. Siliceo, M. and Merida, I. J. Biol. Chem. 284 (17), 11354-11363 (2009). PMID: 19201754
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