|Application ||IHC, E|
|Other Accession||NP_543143.1, NP_955453.1, 122809|
|Calculated MW||50623 Da|
|Other Names||Suppressor of cytokine signaling 4, SOCS-4, Suppressor of cytokine signaling 7, SOCS-7, SOCS4, SOCS7|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SOCS4 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR.|
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Provided below are standard protocols that you may find useful for product applications.
Both variants represent identical protein (NP_543143.1 and NP_955453.1).
Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor
receptor signaling. Kario E, Marmor MD, Adamsky K, Citri A, Amit I, Amariglio N, Rechavi G, Yarden
Y. J Biol Chem. 2005 Feb 25;280(8):7038-48. PMID: 15590694
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