|Application ||WB, E|
|Other Accession||NP_006035.2, 10013|
|Predicted||Rat, Dog, Cow|
|Calculated MW||131419 Da|
|Other Names||Histone deacetylase 6, HD6, 220.127.116.11, HDAC6, KIAA0901|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HDAC6 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.|
|Cellular Location||Nucleus. Cytoplasm. Perikaryon. Cell projection, dendrite. Cell projection, axon. Note=It is mainly cytoplasmic, where it is associated with microtubules|
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Provided below are standard protocols that you may find useful for product applications.
HDAC6 modulates cell motility by altering the acetylation level of cortactin. Zhang X, Yuan Z, Zhang Y, Yong S, Salas-Burgos A, Koomen J, Olashaw N, Parsons
JT, Yang XJ, Dent SR, Yao TP, Lane WS, Seto E. Mol Cell. 2007 Jul 20;27(2):197-213 PMID: 17643370
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