|Application ||IHC, E|
|Other Accession||NP_667338.3, NP_001159608.1, 132884|
|Calculated MW||147948 Da|
|Other Names||Limbin, Ellis-van Creveld syndrome protein 2, EVC2, EVC2, LBN|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||EVC2 / Limbin Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Positive regulator of the hedgehog signaling pathway (By similarity). Plays a critical role in bone formation and skeletal development.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium. Cell projection, cilium membrane Nucleus|
|Tissue Location||Found in the heart, placenta, lung, liver, skeletal muscle, kidney and pancreas|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognise isoform 1 (NP_667338.3) and isoform 2 (NP_001159608.1).
Positional cloning of the gene LIMBIN responsible for bovine chondrodysplastic dwarfism. Takeda H, Takami M, Oguni T, Tsuji T, Yoneda K, Sato H, Ihara N, Itoh T, Kata SR, Mishina Y, Womack JE, Moritomo Y, Sugimoto Y, Kunieda T. Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10549-54. PMID: 12136126
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