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EDD1 / HYD Antibody (C-Term)

Peptide-affinity purified goat antibody

  • IHC - EDD1 / HYD Antibody (C-Term) AF2330a
    AF2330a (4 µg/ml) staining of paraffin embedded Human Testis. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining. These results could not be obtained after antigen retrieval at pH6.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O95071
Other Accession NP_056986.2, 51366, 70790 (mouse), 117060 (rat)
Reactivity Human, Mouse, Rat, Rabbit
Predicted Pig, Cow
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 309352 Da
Additional Information
Gene ID 51366
Other Names E3 ubiquitin-protein ligase UBR5, 6.3.2.-, E3 ubiquitin-protein ligase, HECT domain-containing 1, Hyperplastic discs protein homolog, hHYD, Progestin-induced protein, UBR5, EDD, EDD1, HYD, KIAA0896
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsEDD1 / HYD Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name UBR5
Synonyms EDD, EDD1, HYD, KIAA0896
Function E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'- linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.
Cellular Location Nucleus.
Tissue Location Widely expressed. Most abundant in testis and expressed at high levels in brain, pituitary and kidney
Research Areas
Citations (0)

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EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response. Henderson MJ, Russell AJ, Hird S, Munoz M, Clancy JL, Lehrbach GM, Calanni ST, Jans DA, Sutherland RL, Watts CK. J Biol Chem. 2002 Jul 19;277(29):26468-78. PMID: 12011095

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$ 325.00
Cat# AF2330a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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